Real Madrid is leading Barcelona with one point, and Barca have a game in hand with just one week of the La Liga season remaining.
Barcelona suffer a huge blow in their bid to win the La Liga title after Griezmann sustained an injury to the quadriceps in his right leg and which have been affecting them in big way.
Griezmann underwent tests on Sunday, which confirmed his injury.
Barcelona have two La Liga matches of the season, they will host Osasuna on Thursday before a trip to Alaves next Sunday.
Barca won four of the last five La Liga titles, but if Real madrid win at least two of their final three matches, definitely Barcelona will finish second and need to prepare for next season to get trophy.